![]() The interferon beta drug protocol in amount of 150 IU/g as well as the 4-week protocol of voluntary aerobic exercise with running wheel were administered to the treatment groups. To induce of Experimental Autoimmune Encephalomyelitis (EAE), mixture of myelin oligodendrocyte glycoprotein (MOG) (35-55) was injected subcutaneously, and pertussis toxin was injected intraperitoneally. The Aim of this study was to evaluate the effect of 4 weeks of voluntary aerobic activity along with interferon beta on the serum levels of tumor necrosis factor alfa (TNF-α) and interleukin 10 (IL-10) in mice model of multiple sclerosis.Methods: In this experimental study, a total number of 80 female mice were divided into eight groups. Background: The anti-inflammatory effects of exercise in chronic diseases are mediated by a decrease in pro-inflammatory cytokines and an increase in anti-inflammatory cytokines.
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